Collagen stimulators are the revolution in aesthetic medicine. Unlike classic dermal fillers, they stimulate the body's own collagen production for natural, long-lasting results. In this guide, we compare the three leading collagen stimulators and help you choose.
What are collagen stimulators?
Collagen stimulators are injectable substances that stimulate the body's own collagen production. In contrast to hyaluronic acid fillers, which provide volume immediately, collagen stimulators work gradually over several weeks and months. The result: Natural, long-lasting volume building and skin tightening.
Benefits of collagen stimulators:
- ✅ Long-lasting results (12-24+ months)
- ✅ Natural, gradual improvement
- ✅ Stimulation of the body's own collagen production
- ✅ Skin tightening in addition to volume building
- ✅ Ideal for large-area treatments
The three leading collagen stimulators in comparison
Radiesse: The calcium hydroxyapatite classic
Radiesse by Merz Aesthetics uses calcium hydroxyapatite (CaHA) microspheres in a gel carrier. It provides instant volume plus long-term collagen stimulation.
Available products:
- Radiesse 1 x 1.5 ml – Standard variant for facial contouring and volume building.
- Radiesse Lidocaine 1 x 1.5 ml – With lidocaine for low-pain treatment.
Mechanism of action
The CaHA microspheres provide instant volume while the gel carrier is absorbed. At the same time, the microspheres stimulate the fibroblasts to produce collagen. After 12-18 months the microspheres are completely broken down and the newly formed collagen is retained.
Areas of application
- Cheek and midface structure
- Chin and jaw contouring
- Nasolabial folds (deep folds)
- Back of hand rejuvenation
- Décolleté treatment
Durability & Treatment
Durability: 12-18 months
Treatments: Usually 1-2 sessions
Result: Immediately visible + gradual improvement over 3 months
Advantages: Immediate effect + long-term effect, versatile, proven technology for over 15 years.
Sculptra: The PLLA natural rejuvenation specialist
Sculptra by Galderma is based on poly-L-lactic acid (PLLA), a biocompatible, completely degradable polymer. It is the gold standard for large-scale facial rejuvenation.
Available product:
- Sculptra 2 vials – Complete set with 2 bottles for comprehensive treatment.
Mechanism of action
PLLA microparticles are injected deep into the tissue and stimulate collagen production for months. The result develops gradually over 3-6 months. The PLLA is completely broken down into water and CO₂.
Areas of application
- Large-scale facial rejuvenation
- Building volume if you lose face (e.g. after weight loss)
- Cheek and temple area
- Nasolabial folds
- Marionette wrinkles
- HIV-associated lipoatrophy
Durability & Treatment
Durability: 24+ months (up to 3 years)
Treatments: Usually 2-3 sessions spaced 4-6 weeks apart
Result: Gradually over 3-6 months, very natural
Advantages: Longest lasting, very natural results, ideal for large area treatments, FDA approved since 2004.
Ellansé: The PCL innovation with variable durability
Ellansé by Sinclair uses polycaprolactone (PCL) microspheres. The innovation: Different formulations for different shelf lives.
Available products:
- Ellansé S 2 x 1 ml – Short: 12 month shelf life. Ideal for first treatments.
- Ellansé M 2 x 1 ml – Medium: 18 month shelf life. Most popular variant.
Note: Ellansé L (24 months) and Ellansé E (36+ months) are also available.
Mechanism of action
PCL microspheres in a CMC gel carrier provide instant volume. The microspheres stimulate collagen production while gradually breaking down. The degradation rate varies depending on the formulation (S/M/L/E).
Areas of application
- Facial contouring and volume building
- Cheeks and midface
- Nasolabial folds
- Marionette wrinkles
- Chin and jaw contouring
- Back of hand rejuvenation
Durability & Treatment
Durability: 12-36+ months (depending on variant)
Treatments: Usually 1-2 sessions
Result: Immediately visible + gradual improvement over 3-6 months
Advantages: Immediate effect, variable durability selectable, very good tolerance, CE certified.
Comparison table: Radiesse vs. Sculptra vs. Ellansé
| property | Radiesse | Sculptra | Ellansé |
|---|---|---|---|
| active ingredient | Calcium hydroxyapatite (CaHA) | Poly-L-lactic acid (PLLA) | Polycaprolactone (PCL) |
| Instant effect | ✅ Yes | ❌ No (gradually) | ✅ Yes |
| Durability | 12-18 months | 24+ months | 12-36+ months (variable) |
| Treatments | 1-2 sessions | 2-3 sessions | 1-2 sessions |
| Result | Immediately + gradually | Gradual (3-6 months) | Immediately + gradually |
| Ideal for | Cheeks, chin, hands | Large-scale rejuvenation | Facial contouring |
| Special feature | Proven classic | Longest shelf life | Variable durability |
Frequently Asked Questions (FAQ)
What is the difference to hyaluronic acid fillers?
Hyaluronic acid fillers give immediate volume but completely break down after 6-18 months. Collagen stimulators stimulate the body's own collagen production - the newly formed collagen is partially retained even after the product has been broken down. Result: More natural and longer lasting.
Which collagen stimulator is the best?
There is no such thing as “the best” – everyone has their strengths:
• Radiesse: Ideal if you want immediate results + long-term effects
• Sculptra: Best choice for very natural, long-lasting results (24+ months)
• Ellansé: Perfect if you want to choose the shelf life yourself (12-36 months)
How long does it take to get the final result?
• Radiesse & Ellansé: Immediate effect visible, final result after 3 months
• Sculptra: Gradual buildup over 3-6 months, very natural
Are collagen stimulators reversible?
No, in contrast to hyaluronic acid fillers, collagen stimulators cannot be dissolved with hyaluronidase. Therefore, careful treatment planning by experienced practitioners is important. However, the products decompose completely biologically.
Who are collagen stimulators suitable for?
Ideal for patients aged 35-40 and over with:
• Loss of volume in the face
• Sagging skin
• Desire for natural, long-lasting results
• Large treatment areas
How much do collagen stimulator treatments cost?
The costs vary depending on the product and scope of treatment. In our shop you will find all products at fair prices. Please note that 1-3 treatments are usually necessary - but the long-term effect makes this economically attractive.
Conclusion: Make the right choice
Choosing the right collagen stimulator depends on your goals:
- Want an immediate effect? → Radiesse or Ellansé
- Maximum durability? → Sculptra (24+ months)
- Choose your own durability? → Ellansé (S/M/L/E)
- Large-scale rejuvenation? → Sculptra
- Proven technology? → Radiesse (since 2006)
- Hands/cleavage? → Radiesse
All collagen stimulators in our shop are original products from renowned manufacturers and are delivered quickly and discreetly. If you have any questions about product selection, we will be happy to advise you!
Important note: Collagen stimulators are medical devices and may only be used by qualified medical professionals with appropriate experience. Careful treatment planning is essential.