Hyaluronic acid joint injections: The modern solution for osteoarthritis
Hyaluronic acid injections have been established as an effective, non-surgical treatment method for joint osteoarthritis. In this comprehensive guide, we compare the leading preparations of 2026 in terms of duration of action, costs and areas of application.
What are Hyaluronic Acid Joint Injections?
Hyaluronic acid is a natural component of synovial fluid that acts as a lubricant and shock absorber. With osteoarthritis, the quality and quantity of hyaluronic acid in the joint decreases. Targeted injections improve joint function, reduce pain and increase mobility.
The leading hyaluronic acid preparations in comparison
Ostenil Plus – The classic with mannitol
Duration of action: 6-12 months
Special feature: Contains mannitol as an antioxidant for additional joint protection
Application: Knee, hip and shoulder joints
Advantages: Clinically proven, high tolerability, long-lasting effect
→ Order Ostenil Plus 40 mg 2 ml now
Synvisc One – The single-shot solution
Duration of action: Up to 6 months
Special feature: Only one injection required (instead of 3-5)
Application: Primarily knee joint
Advantages: Patient-friendly, time-saving, high-molecular hyaluronic acid
→ Order Synvisc One 48 mg 6 ml now
Cingal – Innovation with corticosteroid
Duration of action: Up to 6 months
Special feature: Combination of hyaluronic acid and triamcinolone for immediate pain relief
Application: Knee joint in acute pain
Advantages: Fast onset of action, long-lasting effect, single shot
HyalOne – The highly concentrated version
Duration of action: 6-9 months
Special feature: 60 mg of hyaluronic acid in 4 ml - high concentration
Application: Large joints (knees, hips)
Advantages: High viscosity, good joint lubrication
→ Order HyalOne 60 mg 4 ml now
Durolane – The long-term effect
Duration of action: Up to 12 months
Special feature: NASHA technology (Non-Animal Stabilized Hyaluronic Acid)
Application: All major joints
Advantages: Longest duration of action, only one injection per year
→ Order Durolane 60 mg 3 ml now
Costs and profitability
The cost of hyaluronic acid injections varies depending on the preparation and treatment regimen:
- Single injections (Synvisc One, Cingal, Durolane): Higher individual costs, but only one treatment
- Multiple injections (Ostenil, HyalOne): Lower individual cost but requires 3-5 sessions
- Long-term effects: Durolane offers the best cost-benefit ratio with up to 12 months
Which patients are joint injections suitable for?
Hyaluronic acid injections are particularly suitable for:
- Patients with mild to moderate knee osteoarthritis
- People who want to avoid surgical procedures
- Athletes with joint wear
- Patients for whom NSAIDs are contraindicated
- Supplement to physiotherapeutic measures
Application and treatment process
The injection is carried out under sterile conditions directly into the affected joint. Depending on the preparation, 1-5 injections are required one week apart. The treatment is usually well tolerated and can be carried out on an outpatient basis.
Scientific evidence and study situation
Numerous clinical studies prove the effectiveness of hyaluronic acid injections for osteoarthritis. Meta-analyses show significant improvements in pain and function, particularly in knee osteoarthritis. The effects typically begin after 2-4 weeks and last for several months.
Combination with other therapies
For optimal results, hyaluronic acid injections can be combined with:
- Physiotherapy and targeted muscle building
- Weight reduction if you are overweight
- Dietary supplements (glucosamine, chondroitin)
- Physical therapies (ultrasound, electrotherapy)
Safety and side effects
Hyaluronic acid injections are considered safe. Possible side effects are mostly mild and include:
- Local swelling or redness (1-2 days)
- Mild pain at the injection site
- Rare: joint effusion or allergic reactions
Conclusion: Which preparation is the right one?
For maximum patient friendliness: Synvisc One or Cingal (single shot)
For longest duration of action: Durolane (up to 12 months)
For acute pain: Cingal (with corticosteroid)
For proven standard therapy: Ostenil Plus
For large joints: HyalOne (high concentration)
Other recommended joint injections
In addition to the main products, we also offer other high-quality hyaluronic acid preparations:
- Go-On 25 mg 2.5 ml – Proven joint therapy with practical dosage
- Synvisc 16 mg 2 ml (3 pcs.) – Classic multiple injection therapy
- Recosyn 20 mg 2 ml – Highly effective alternative
- Ostenil 20 mg 2 ml – Standard dosage for medium joints
Frequently Asked Questions (FAQ)
How long do hyaluronic acid injections last?
The duration of action varies between 6 and 12 months depending on the preparation. Durolane offers the longest effect, lasting up to 12 months Synvisc One and Cingal lasts about 6 months.
Are hyaluronic acid injections painful?
The injection itself is usually only minimally painful. Many preparations like Cingal contain local anesthetics for added comfort. Mild, temporary discomfort may occur after the injection.
How many injections are necessary?
That depends on the preparation you choose. Single shot solutions like Synvisc One, Cingal or Durolane require only one injection. Other preparations such as Ostenil Plus are administered in 3-5 weekly sessions.
Does the health insurance company cover the costs?
The cost coverage varies depending on the health insurance company and individual situation. In Germany, statutory health insurance companies usually do not cover the costs as standard. Private insurance companies reimburse more frequently. Prior clarification with the health insurance company is recommended.
Which joints are hyaluronic acid injections suitable for?
Hyaluronic acid injections are most commonly used in the knee joint, but are also suitable for the hip, shoulder, ankle and smaller joints. Durolane is approved for all large joints.
When does the effect occur?
The pain-relieving effect typically begins after 2-4 weeks. Cingal offers noticeable improvement after just a few days thanks to the corticosteroid it contains.
Are there any side effects?
Hyaluronic acid injections are very well tolerated. Possible side effects include local swelling, redness or slight pain at the injection site, which usually subsides after 1-2 days. Serious side effects are very rare.
Can the treatment be repeated?
Yes, hyaluronic acid injections can be repeated if necessary. Once the duration of action has expired (6-12 months), treatment can be repeated. Many patients benefit from regular annual injections.
Professional advice for practices and pharmacies
As a specialist in medical aesthetics and orthopedic preparations, we offer you:
✓ Original products from all leading manufacturers
✓ Fast delivery and reliable availability
✓ Expert advice on product selection and application
✓ Attractive conditions for practices and pharmacies
✓ GMC compliant product data and documentation
→ Contact us now and get advice
Medical Notice: This article is for informational purposes only and is not a substitute for medical advice. Hyaluronic acid injections should only be used by qualified medical professionals. Always consult a specialist for an individual diagnosis and treatment recommendation.