Synvisc One 48 mg 6 ml
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Synvisc One 48 mg 6 ml - The single injection with Hylan G-F 20
Special hyaluronic acid polymer for up to 6 months of action | Original Sanofi Aventis
Buy Synvisc One - The gold standard for knee osteoarthritis
Synvisc One 48 mg from Sanofi-Aventis is the globally proven single-use hyaluronic acid injection with the special active ingredient Hylan G-F 20. This unique hyaluronic acid polymer provides up to 6 months of support for knee osteoarthritis (gonarthrosis) with just ONE injection and significantly reduces the number of doctor visits.
Why Synvisc One? The advantages at a glance
- Only ONE injection: Instead of 3-5 treatments - maximum comfort
- Up to 6 months duration of action: Long-lasting support
- Hylan G-F 20 Polymer: Specially developed for a long stay
- Proven worldwide: Over 25 years of clinical experience
- Sanofi-Aventis quality: Highest production standards
- Pre-filled syringe 6 ml: Simple, safe application
- Fewer doctor visits: Time and cost savings
- Especially for knees: Optimized for knee osteoarthritis
Technical product data Synvisc One 48 mg
| property | Specification |
|---|---|
| active ingredient | Hylan G-F 20 (48 mg total) |
| Concentration | 8mg/ml |
| Volume per syringe | 6ml |
| Special feature | Hylan polymer (cross-linked HA) |
| Duration of action | Up to 6 months |
| Origin HA | Non-animal (bacterial fermentation) |
| pH value | 7,0-7,5 |
| Viscosity | Very high (polymer structure) |
| Dosage form | Sterile pre-filled syringe |
| Manufacturer | Sanofi Aventis |
| Certification | CE-MDR certified |
Areas of application - When is Synvisc One used?
Synvisc One is specifically indicated for the symptomatic treatment of:
- Knee joint osteoarthritis (gonarthrosis): Primary indication
- Mild to moderate osteoarthritis: Ideally suited
- Pain relief: For pain under stress and at rest
- Restriction of movement: Improving mobility
- Alternative to painkillers: Reducing NSAIDs
What is Hylan G-F 20? The special active ingredient
Synvisc One includes Hylan G-F 20, a specially developed hyaluronic acid polymer that differs from standard hyaluronic acid:
🔬 Hylan G-F 20 properties:
- Cross-linked polymer: Chemically modified hyaluronic acid for greater stability
- Higher viscosity: Better joint lubrication than native HA
- Longer stay: Remains in the joint for up to 6 months
- Elastoviscous: Optimal shock absorption and lubrication
- Clinically proven: Over 25 years of experience worldwide
How does Synvisc One work? The mechanism of action
Synvisc One works through several mechanisms:
- Joint lubrication: Improves synovial fluid viscosity
- Shock absorption: Increases the viscoelastic properties of the joint
- Cartilage protection: Reduces friction and mechanical stress
- Pain relief: Mechanical relief leads to less pain
- Anti-inflammatory: Supports natural joint function
Synvisc One vs. Standard Hyaluronic Acid - The Comparison
| feature | Synvisc One | Standard HA |
|---|---|---|
| active ingredient | Hylan G-F 20 (polymer) | Native hyaluronic acid |
| Number of injections | 1 injection | 3-5 injections |
| Volume | 6ml | 2-3 ml |
| Duration of action | Up to 6 months | 3-4 months |
| Doctor visits | 1 visit | 3-5 visits |
| Viscosity | Very high (polymer) | Default |
| Clinical experience | 25+ years | Variable |
Application & dosage
Recommended treatment regimen:
- Standard therapy: 1 injection of 6 ml intra-articularly into the knee joint
- Repeat therapy: After 6 months if necessary
- Injection volume: 6 ml (complete syringe)
- Application: Only by medical professionals
- Injection technique: Intraarticularly under sterile conditions
Scope of delivery Synvisc One 48 mg
✓ 1 pre-filled syringe of 6 ml (48 mg Hylan G-F 20)
✓ 1 sterile injection cannula
✓ Package leaflet with instructions for use
✓ CE certificate of conformity
✓ Batch documentation
Storage & Shelf Life
- Store at room temperature (below 25°C)
- Protect from direct sunlight
- Do not freeze
- Store in original packaging
- Shelf life: See packaging (typically 24-36 months)
Frequently Asked Questions (FAQ)
❓ How long does Synvisc One last?
The duration of action of Synvisc One is usually: up to 6 months, depending on the severity of knee osteoarthritis and individual factors. The special Hylan G-F 20 polymer ensures a particularly long stay in the joint.
❓ How many injections are necessary?
The big advantage of Synvisc One: It will just ONE injection required, as opposed to 3-5 injections for standard hyaluronic acid. This means just one visit to the doctor and maximum comfort for the patient.
❓ How much does Synvisc One cost?
The price for medical professionals is: €149.50 per pre-filled syringe (plus VAT). Quantity discounts on request. Despite the higher unit price, Synvisc One is often more cost-effective because only one treatment is necessary.
❓ When does the effect begin?
The first improvements usually become apparent after a while 1-2 weeks. The maximum effect is achieved after 4-8 weeks and then lasts up to 6 months.
❓ What is the difference between Synvisc and Synvisc One?
Synvisc One is the disposable version with 6 ml in a syringe. Synvisc (classic) is administered in 3 injections of 2 ml each. Both contain Hylan G-F 20, but Synvisc One offers more comfort with just one treatment.
❓ Which joints is Synvisc One suitable for?
Synvisc One is especially for the knee joint developed and approved. There are other hyaluronic acid preparations that are more suitable for other joints (hips, shoulders, etc.).
❓ Does Synvisc One require a prescription?
No, Synvisc One does not require a prescription. You can receive Synvisc One without a doctor's prescription. However, it is only used by qualified medical professionals in clinics, practices or hospitals.
❓ Can Synvisc One be combined with other treatments?
Yes, Synvisc One can Physiotherapy, weight loss and moderate exercise be combined. The combination with other intra-articular injections should be discussed with the attending physician.
❓ Are there any side effects?
Synvisc One is generally well tolerated. Occasionally can local reactions such as swelling, pain or warmth at the injection site, which usually goes away within a few days. Serious side effects are rare.
Scientific Evidence & Studies
Synvisc One is based on over 25 years of clinical experience with Hylan G-F 20. Numerous studies show:
✓ Significant pain reduction in knee osteoarthritis patients over 6 months
✓ Improvement in joint function and mobility (WOMAC score)
✓ Good tolerance with few side effects
✓ High patient satisfaction thanks to single use
✓ Cost efficiency through reduced doctor visits
✓ Superiority over placebo in controlled trials
✓ Long-term studies confirm lasting effects
Why buy from FitTec?
✓ Original Sanofi-Aventis products - Directly from the manufacturer
✓ Fast shipping - Delivery within 1-3 working days
✓ Quantity discounts - Attractive graduated prices for practices
✓ Specialist advice - Competent support
✓ Secure payment - Medical facility bill
✓ Batch documentation - Full traceability
✓ Large stocks - Immediate availability
Further information
📚 Hyaluronic acid for osteoarthritis: effect, costs & best preparations 2025
📚 Treating knee osteoarthritis: All methods in comparison 2025
📚 Hyaluronic acid injections comparison - The ultimate guide 2025
📚 Synvisc One - The single injection with Hylan polymer for knee osteoarthritis
Legal notice: Medical device according to MDR (EU) 2017/745. CE certified. Sales exclusively to medical professionals (doctors, clinics, hospitals, pharmacies). Not for self-medication. The application is carried out by qualified medical professionals. Please note the instructions for use.
- Type Hyaluronic acid injection for joints
- Manufacturer Sanofi-Aventis
- PZN 03390734