Sculptra 2 vials

Sculptra: PLLA collagen stimulator for natural facial rejuvenation

Sculptra from Galderma is the innovative collagen stimulator with poly-L-lactic acid (PLLA) for large-scale, natural facial rejuvenation. Stimulates the body's collagen production for gradual, long-lasting results up to 24+ months - the longest lasting collagen stimulator on the market.

Product details

• Manufacturer: Galderma
• Contents: 2 vials (bottles)
• Active ingredient: Poly-L-lactic acid (PLLA)
• PLLA content: 367.5 mg per vial
• Dosage form: Lyophilisate for reconstitution
• Special feature: Longest shelf life of all collagen stimulators
• Duration of action: 24+ months (up to 3 years)
• Origin: USA

Areas of application

• Large-scale facial rejuvenation
• Building volume in the event of facial loss
• Cheek and temple area
• Nasolabial folds
• Marionette wrinkles
• Chin line and jawline contour
• HIV-associated lipoatrophy
• Age-related volume loss

Benefits of Sculptra

✅ Longest shelf life: 24+ months, up to 3 years
✅ Natural, gradual results: development over 3-6 months
✅ Collagen stimulation: Activates the body's own production
✅ Large-area treatment: Ideal for the entire face
✅ FDA Approved: Clinically proven since 2004
✅ Biocompatible: PLLA is completely degraded
✅ Long-term rejuvenation: Sustainable skin improvement
✅ Natural Appearance: No sudden changes

How does Sculptra work?

Sculptra uses poly-L-lactic acid (PLLA) to stimulate the body's own collagen production:

Phase 1 – Injection (Day 1):

• PLLA microparticles are injected deep into the tissue
• Immediate, light volume effect through injection fluid
• PLLA particles spread throughout the tissue

Phase 2 – Collagen Stimulation (Weeks 1-12):

• PLLA microparticles activate fibroblasts
• The body's own collagen production is stimulated
• New collagen forms around the PLLA particles
• Gradual volume build-up begins

Phase 3 – Maximum Effect (Months 3-6):

• Collagen production reaches maximum
• Visible volume increase and skin tightening
• Natural, rejuvenated look
• Improving skin quality

Phase 4 – Long-term effects (months 6-24+):

• New collagen is retained
• PLLA slowly breaks down into water and CO₂
• Results last 24+ months
• Up to 3 years of effectiveness possible

Sculptra vs. hyaluronic acid fillers

Sculptra (collagen stimulator):

• Stimulates the body's own collagen production
• Gradual results over 3-6 months
• Very natural look
• 24+ month shelf life (up to 3 years)
• Ideal for large-area treatments
• Sustainably improves skin quality
• Poly-L-lactic acid (PLLA)

Hyaluronic acid fillers:

• Direct volume build-up
• Instant results
• Visible change immediately after treatment
• 6-18 months shelf life
• Ideal for targeted areas
• Fills wrinkles directly
• Hyaluronic acid (HA)

Sculptra vs. other collagen stimulators

Sculptra (PLLA):

• Active ingredient: Poly-L-lactic acid
• Shelf Life: 24+ months (up to 3 years)
• Onset of action: Gradually over 3-6 months
• Ideal for: Large-scale rejuvenation
• Special feature: Longest shelf life

Radiesse (CaHA):

• Active ingredient: calcium hydroxyapatite
• Shelf life: 12-18 months
• Onset of action: Immediately + gradually
• Ideal for: Instant volume + collagen stimulation
• Special feature: immediate effect + long-term effect

Ellansé (PCL):

• Active ingredient: polycaprolactone
• Shelf life: 12-48 months (depending on version)
• Onset of action: Immediately + gradually
• Ideal for: facial contouring
• Special feature: Variable durability (S/M/L/E)

Technical information

Treatment protocol

• Number of sessions: 2-3 treatments at intervals of 4-6 weeks
• Preparation: Reconstitution at least 2 hours beforehand (ideally 24-72 hours)
• Injection technique: Fanning, cross-hatching, linear threading
• Injection depth: Deep dermis to subcutaneous
• Needle size: 25-26G
• Massage: Immediately after injection and 5 times a day for 5 minutes for 5 days (5-5-5 rule)
• Onset of effect: Gradually over 3-6 months
• Maximum effect: After 3-6 months
• Duration of action: 24+ months (up to 3 years)
• Refresher: Possible after 18-24 months

Reconstitution & Preparation

• Sculptra is supplied as a lyophilisate (powder).
• Reconstitute with 5-8 ml sterile water per vial
• At least 2 hours of rest time (ideally 24-72 hours)
• Shake well before injection to ensure uniform suspension
• Use within 72 hours of reconstitution

Storage

• Lyophilisate: Store at room temperature (below 25°C).
• Protect from direct sunlight
• Do not freeze
• Store in original packaging
• After reconstitution: Store in the refrigerator, use within 72 hours

Scope of delivery

• 2 vials of Sculptra lyophilisate (367.5 mg PLLA each)
• Package leaflet
• Certificate of Conformity
• Reconstitution instructions

Frequently asked questions

How long does Sculptra last?
Sculptra lasts 24+ months, in many cases up to 3 years. It is the longest lasting collagen stimulator on the market.

How many treatments do I need?
Typically 2-3 treatments spaced 4-6 weeks apart for optimal results.

When will I see results?
Results develop gradually over 3-6 months. This ensures a very natural look without any sudden changes.

Is the treatment painful?
The treatment can be slightly uncomfortable. Local anesthesia or numbing cream is usually used.

What is the 5-5-5 rule?
After the treatment, you should massage the treated area 5 times a day for 5 minutes each for 5 days to ensure even distribution.

Who is Sculptra suitable for?
Ideal for people aged 30 and over with facial volume loss who want natural, long-lasting results.

What is the difference between Sculptra and Radiesse?
Sculptra (PLLA) offers the longest durability (24+ months) with gradual results. Radiesse (CaHA) provides instant volume plus collagen stimulation with 12-18 month shelf life.

Can I combine Sculptra with fillers?
Yes, Sculptra can be perfectly combined with hyaluronic acid fillers. Sculptra for large-area rejuvenation, filler for targeted areas.

More information

Collagen stimulators in comparison: Radiesse vs. Sculptra vs. Ellansé – The Ultimate Guide 2025

All hyaluronic acid products: Hyaluronic acid injections comparison 2025

More about Sculptra: PLLA collagen stimulator for natural facial rejuvenation

Important note: This medical device is intended exclusively for use by qualified healthcare professionals with appropriate Sculptra experience. Please note the instructions for use and specialist information.